The CEO of the Iranian Rare Diseases Foundation links the high prevalence of rare diseases in Iran to consanguineous marriages, emphasizing the need for genetic counseling and preventive measures.

"Familial marriages are the primary cause of the high prevalence of rare diseases in Iran, a situation unmatched by other countries," Hamid Reza Adraki said, adding, "Addressing this issue requires greater emphasis on genetic counseling and a reduction in familial marriages."

In Middle Eastern and Southern Indian populations, consanguineous marriages are commonly practiced.

Consanguineous marriage refers to a union between individuals who are second cousins or closer. First-cousin parents face an elevated risk of having a child with an autosomal recessive disease, and the likelihood of fetal loss from such disorders is higher compared to the general population.